Chang Lab for Liver Tissue Engineering - Homepage
Translating Regenerative Surgery on the Liver From Concept to Therapeutic Reality
Tissue engineering and regeneration are the next evolutionary step in surgical practice. As surgeons, we resect, reconstruct, and transplant to treat a diverse array of diseases resulting from acute inflammation, congenital malformation, malignancy, or organ failure. In the near future, our armamentarium will increase to include using our surgical skills to induce tissue regeneration in situ or to implant ex vivo engineered organs. Accelerating advances in biotechnology, stem cell biology, and minimally invasive surgery are ripe for convergence, which will lead to the creation of novel surgical treatments to replace diseased or dysfunctional tissues. Our lab's goal is to make significant contributions to bringing these regenerative surgical therapies from the lab into the operating room.
Featured Publications
- Metastatic melanoma to small bowel: metastasectomy is supported in the era of immunotherapy and checkpoint inhibitors.
2024 | PubMed - Irreversible Electroporation of the Liver Increases the Transplant Engraftment of Hepatocytes.
2023 | PubMed - Isochoric Supercooling Organ Preservation System.
2023 | PubMed - An exploratory study on isochoric supercooling preservation of the pig liver.
2023 | PubMed - Self-Assembled Matrigel-Free iPSC-Derived Liver Organoids Demonstrate Wide-Ranging Highly Differentiated Liver Functions.
2023 | PubMed